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Induction of Autoantibodies to Syngeneic Prostate-specific Membrane Antigen by Xenogeneic Vaccination by Polly D. Gregor; Jedd D. Wolchok; Vandana Turaga; Jean-Baptiste Latouche; Michel Sadelain; Dean Bacich; Warren D.W. Heston; Alan N. Houghton; Howard I. Scher is a Medicine article available to read on EtoBox.
What is Induction of Autoantibodies to Syngeneic Prostate-specific Membrane Antigen by Xenogeneic Vaccination about?
## Abstract Prostate‐specific membrane antigen (PSMA) is a prototypical differentiation antigen expressed on normal and neoplastic prostate epithelial cells, and on the neovasculature of many solid tumors. Monoclonal antibodies specific for PSMA are in development as therapeutic agents. Methodologies to actively immunize against PSMA may be limited by immunologic ignorance and/or tolerance that restrict the response to self‐antigens. Our studies have previously shown that xenogeneic immunization with DNA vaccines encoding melanosomal differentiation antigens induces immunity in a mouse melanoma model. Here we apply this approach to PSMA to establish proof of principle in a mouse model. Immunization with xenogeneic human PSMA protein or DNA induced antibodies to both human and mouse PSMA in mice. Monoclonal antibodies specific for mouse PSMA were generated to analyze antibody isotypes and specificity for native and denatured PSMA at the clonal level. Most antibodies recognized denatured PSMA, but C57BL/6 mice immunized with xenogeneic __PSMA__ DNA followed by a final boost with xenogeneic PSMA protein yielded autoantibodies that reacted with native folded mouse PSMA. Monoclonal anti
Who reads Induction of Autoantibodies to Syngeneic Prostate-specific Membrane Antigen by Xenogeneic Vaccination?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Polly D. Gregor; Jedd D. Wolchok; Vandana Turaga; Jean-Baptiste Latouche; Michel Sadelain; Dean Bacich; Warren D.W. Heston; Alan N. Houghton; Howard I. Scher
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)