Opening book details…
Can I read miR-455-3p Functions as a Tumor Suppressor by Restraining Wnt/Î2-Catenin Signaling via TAZ in Pancreatic Cancer on EtoBox?
miR-455-3p Functions as a Tumor Suppressor by Restraining Wnt/Î2-Catenin Signaling via TAZ in Pancreatic Cancer by Zhan, Ting; Zhu, Qingxi; Han, Zheng; Tan, Jie; Liu, Meng; Liu, Weijie; Chen, Wei; Chen, Xiaoli; Chen, Xueting; Deng, Junsheng; Tian, Xia; Huang, Xiaodong is a Medicine article available to read on EtoBox.
What is miR-455-3p Functions as a Tumor Suppressor by Restraining Wnt/Î2-Catenin Signaling via TAZ in Pancreatic Cancer about?
## Background Pancreatic cancer (PC) is a highly invasive tumor with a poor prognosis, short overall survival rate and few chemotherapeutic choices. Despite the importance of finding ways to treat pancreatic cancer, the mechanisms of tumor progression have not been fully elucidated. microRNA-455-3p (miR-455-3p) has been reported to play an important role in several cancers, but its function in pancreatic cancer remains unclear. ## Methods To investigate the biological functions, miRNAs mimics or inhibitors were transfected into pancreatic cancer cells. Flow cytometry was used to detect cell apoptosis. Wound healing and Transwell assays were employed to observe cell invasion and migration abilities. The expression of Bcl-2, Bax, caspase-3, E-cadherin, N-cadherin, Snail, β-Catenin, c-Myc and Cyclin D1 were evaluated by qPCR and Western blot. ## Results We confirmed that inhibition of miR-455-3p decreases cell apoptosis and increases cell migration, invasion and EMT of pancreatic cancer, whereas forced overexpression of miR-455-3p has the opposite effect. Furthermore, we demonstrated that the tumor suppression effects of miR-455-3p were partially reversed by TAZ overexpression. In add
Who reads miR-455-3p Functions as a Tumor Suppressor by Restraining Wnt/Î2-Catenin Signaling via TAZ in Pancreatic Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Zhan, Ting; Zhu, Qingxi; Han, Zheng; Tan, Jie; Liu, Meng; Liu, Weijie; Chen, Wei; Chen, Xiaoli; Chen, Xueting; Deng, Junsheng; Tian, Xia; Huang, Xiaodong
- Publisher
- Dove Press Ltd.; Dove Medical Press; Dove Medical Press Ltd; [Auckland N.Z.]: Dove Medical Press, c2009-; Informa UK Limited; Dove Medical Press Ltd. (ISSN 1179-1322)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)