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RRM2 Inhibition Alters Cell Cycle Through ATMRbE2F1 Pathway in Atypical Teratoid Rhabdoid Tumor by huyenxiu2001 is a document available to read on EtoBox.
The study investigates the effects of RRM2 inhibition on the cell cycle in atypical teratoid rhabdoid tumor (ATRT) through the ATM/Rb/E2F1 pathway. It finds that COH29, an RRM2 inhibitor, induces DNA damage, activates ATM, and promotes Rb-E2F1 interaction, leading to cell cycle arrest and apoptosis. These findings suggest that targeting the ATM/Rb/E2F1 pathway could be a promising therapeutic strategy for treating ATRT.
- Author
- huyenxiu2001
- Language
- EN