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Why Hereditary Nonpolyposis Colorectal Carcinoma Patients Appear to Have Better Survival Than Patients with Sporadic Colorectal Carcinoma by R. A. Sheikh; B. H. Min; R. Teplitz; H. Tesluk; B. H. Ruebner; M. J. Lawson is a Medicine article available to read on EtoBox.

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Is Flow Cytometry a Useful Test? R epresenting a busy flow cytometry laboratory with an annual workload of approximately 1400 acute leukemia and malignant lymphoma cases, we read the article by Naughton et al. 1 with considerable interest. The authors concluded that "flow cytometry of bone marrow aspirates has a limited role in the routine staging and follow-up of patients with an established diagnosis of [non-Hodgkin's lymphoma] NHL." 1 However, this conclusion must be challenged because a number of methodologic flaws and inadequacies in the process, analysis, and interpretation are evident in this study. 2,3 The authors used Ficoll-Paque (Pharmacia Biotech, Piscataway, NJ) processed specimens rather than recommended erythrocyte lysis. 2 Ficoll-Paque centrifugation of bone marrow aspirates is known to result in the selective loss of some cell populations. This phenomenon is related to the fact that neoplastic lymphoid cells may have a different buoyant density from normal lymphocytes and may not be found where anticipated in the gradient. 2 The authors, possibly unknowingly, thus may have reduced the number of potentially analyzable malignant lymphoid cells in their samples, which

Who reads Why Hereditary Nonpolyposis Colorectal Carcinoma Patients Appear to Have Better Survival Than Patients with Sporadic Colorectal Carcinoma?

Author

R. A. Sheikh; B. H. Min; R. Teplitz; H. Tesluk; B. H. Ruebner; M. J. Lawson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1999

Language

EN

Field

Medicine (Health Sciences)