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Can I read RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line on EtoBox?
RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line by Naohito Sato; Takayuki Fukui; Tetsuo Taniguchi; Toshihiko Yokoyama; Masashi Kondo; Tetsuro Nagasaka; Yasuhiro Goto; Wentao Gao; Yuichi Ueda; Kohei Yokoi; John D. Minna; Hirotaka Osada; Yutaka Kondo; Yoshitaka Sekido is a Medicine article available to read on EtoBox.
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## Abstract Identification of a homozygous deletion in cancer cells provides strong evidence for the location of a tumor suppressor gene (TSG). We analyzed the 2p24 homozygous deletion of a non‐small‐cell lung cancer (NSCLC) cell line, NCI‐H2882, and found that the deletion size was 3.7 Mbp. Since __RhoB__, which has been suggested to be a candidate TSG, was located in this region, we analyzed __RhoB__ for alterations in NSCLC. Although we found no mutations in 48 cell lines including 20 NSCLCs, a loss of heterozygosity (LOH) analysis in 128 primary NSCLCs showed that 25 of 62 informative samples had LOH at the __RhoB__ locus. Northern blot analysis of 28 cell lines (including 15 NSCLCs) indicated that __RhoB__ expression was downregulated in 27. We analyzed RhoB expression in 112 primary NSCLCs with immunohistochemistry and found no or a weak RhoB expression in 33 (42%) of 78 adenocarcinomas, whereas we found it in 29 (94%) of 31 squamous cell carcinomas. No or a weak expression of RhoB was more frequently observed in poorly‐ or moderately‐differentiated adenocarcinomas than in well‐differentiated ones (__p__ = 0.0014). Furthermore, no or a weak expression of RhoB indicated a tend
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- Author
- Naohito Sato; Takayuki Fukui; Tetsuo Taniguchi; Toshihiko Yokoyama; Masashi Kondo; Tetsuro Nagasaka; Yasuhiro Goto; Wentao Gao; Yuichi Ueda; Kohei Yokoi; John D. Minna; Hirotaka Osada; Yutaka Kondo; Yoshitaka Sekido
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)