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Deep sequencing of sncRNAs reveals hallmarks and regulatory modules of the transcriptome during Parkinson’s disease progression by Fabian Kern; Tobias Fehlmann; Ivo Violich; Eric Alsop; Elizabeth Hutchins; Mustafa Kahraman; Nadja L. Grammes; Pedro Guimarães; Christina Backes; Kathleen L. Poston; Bradford Casey; Rudi Balling; Lars Geffers; Rejko Krüger; Douglas Galasko; Brit Mollenhauer; Eckart Meese; Tony Wyss-Coray; David W. Craig; Kendall Van Keuren-Jensen; Andreas Keller is a Medicine article available to read on EtoBox.

What is Deep sequencing of sncRNAs reveals hallmarks and regulatory modules of the transcriptome during Parkinson’s disease progression about?

arkinson's disease (PD) is the second most common neurodegenerative disease worldwide 1 but the exact causes for the disease and its progression remain largely unknown 2 . PD seems to result from a complicated interplay of genetic and environmental factors that affect fundamental cellular processes 3 . The diagnosis by means of often heterogeneous symptoms is based on clinical criteria 4 , making validated diagnostic and prognostic biomarkers an unmet demand to support new therapeutic developments.The rapid development of high-throughput screening techniques and declining experimental costs fostered fundamental research on the molecular underpinnings of PD such as genome-or transcriptome-wide association studies to discover marker genes . On the search for low-invasive biomarkers, transcriptome analyses based on a variety of biofluids such as blood or cerebrospinal fluid 13 have been conducted. Until recently, these studies were primarily focused on the coding transcriptome, obtruding the question about the role of noncoding RNAs in PD .As part of the sncRNAs, microRNAs (miRNAs) play a versatile role in post-transcriptional messenger RNA (mRNA) regulation. Owing to their stability,

Who reads Deep sequencing of sncRNAs reveals hallmarks and regulatory modules of the transcriptome during Parkinson’s disease progression?

Author

Fabian Kern; Tobias Fehlmann; Ivo Violich; Eric Alsop; Elizabeth Hutchins; Mustafa Kahraman; Nadja L. Grammes; Pedro Guimarães; Christina Backes; Kathleen L. Poston; Bradford Casey; Rudi Balling; Lars Geffers; Rejko Krüger; Douglas Galasko; Brit Mollenhauer; Eckart Meese; Tony Wyss-Coray; David W. Craig; Kendall Van Keuren-Jensen; Andreas Keller

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Life Sciences)