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Simple and Sensitive High-performance Liquid Chromatography Method for the Quantitation of Indinavir in Rat Plasma and Central Nervous System by Mehrdad Hamidi is a Chemistry article available to read on EtoBox.
What is Simple and Sensitive High-performance Liquid Chromatography Method for the Quantitation of Indinavir in Rat Plasma and Central Nervous System about?
Simple and sensitive high-performance liquid chromatography method for the quantitation of indinavir in rat plasma and central nervous system A simple and sensitive RP-HPLC method using UV detection (215 nm) was developed for the determination of indinavir concentrations in rat plasma, cerebrospinal fluid (CSF), and brain tissue homogenates. Biological samples were processed using a combination of acid pretreatment and liquid -liquid extraction with verapamil used as the internal standard. This method produced a linear response throughout the indinavir concentration range of 0.05 -30 lM in plasma and 0.05 -2.5 lM in CSF and brain with a LOD of 12.5 nM for plasma and CSF, and 6.25 nM for brain homogenate. Due to its high sensitivity, this assay is particularly useful for the quantitative determination of indinavir concentrations in brain and CSF.
Who reads Simple and Sensitive High-performance Liquid Chromatography Method for the Quantitation of Indinavir in Rat Plasma and Central Nervous System?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Mehrdad Hamidi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1615-9306)
- Published
- 2006
- Language
- EN
- Field
- Chemistry (Physical Sciences)