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Applications of the Mitsunobu reaction in peptide chemistry by Kazimierz Wiśniewski; Aleksandra S. Kołdziejczyk; Bogdan Falkiewicz is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Applications of the Mitsunobu reaction in peptide chemistry about?

The Mitsunobu reaction ± the nucleophilic substitution of an alcoholic hydroxyl group mediated by the redox system trialkylphosphine/dialkyl azodicarobxylate ± is widely used in the chemistry of biologically active compounds. The paper deals with applications of the Mitsunobu reaction in amino acid and peptide chemistry. The process provides easy access to many unnatural amino acids and derivatives. Since the reaction occurs with complete inversion of the configuration at the carbinol chiral centre, it can be used for the synthesis of diastereoisomers of hydroxy-and tioprolines. Cyclization of b-hydroxy amino acid containing peptides under Mitsunobu reaction conditions leads to a constrained peptide that mimics the stabilizing reverse turn secondary structure.

Who reads Applications of the Mitsunobu reaction in peptide chemistry?

Author

Kazimierz Wiśniewski; Aleksandra S. Kołdziejczyk; Bogdan Falkiewicz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1075-2617)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)