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Can I read Design and Campaign Synthesis of Piperidine- and Thiazole-based Histone Deacetylase Inhibitors on EtoBox?
Design and Campaign Synthesis of Piperidine- and Thiazole-based Histone Deacetylase Inhibitors by David M. Andrews; Elaine S.E. Stokes; Greg R. Carr; Zbigniew S. Matusiak; Craig A. Roberts; Michael J. Waring; Madeleine C. Brady; Christine M. Chresta; Simon J. East is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Design and Campaign Synthesis of Piperidine- and Thiazole-based Histone Deacetylase Inhibitors about?
A lead benzamide, 3, was identified as a potent and low molecular weight histone deacetylase (HDAC) inhibitor. Optimization led to 16d, demonstrating an excellent balance of efficacy and non-efficacy properties, along with very desirable in vivo DMPK. The final compounds presented are >1000-fold more potent than the initial screen hit, an improvement in potency which was achieved with a concomitant significant improvement in all the main non-efficacy properties.
Who reads Design and Campaign Synthesis of Piperidine- and Thiazole-based Histone Deacetylase Inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- David M. Andrews; Elaine S.E. Stokes; Greg R. Carr; Zbigniew S. Matusiak; Craig A. Roberts; Michael J. Waring; Madeleine C. Brady; Christine M. Chresta; Simon J. East
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)