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Single Locus Affects Embryonic Segment Polarity and Multiple Aspects of an Adult Evolutionary Novelty by Suzanne V Saenko; Paul M Brakefield; Patrícia Beldade is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract ## Background The characterization of the molecular changes that underlie the origin and diversification of morphological novelties is a key challenge in evolutionary developmental biology. The evolution of such traits is thought to rely largely on co-option of a toolkit of conserved developmental genes that typically perform multiple functions. Mutations that affect both a universal developmental process and the formation of a novelty might shed light onto the genetics of traits not represented in model systems. Here we describe three pleiotropic mutations with large effects on a novel trait, butterfly eyespots, and on a conserved stage of embryogenesis, segment polarity. ## Results We show that three mutations affecting eyespot size and/or colour composition in __Bicyclus anynana__ butterflies occurred in the same locus, and that two of them are embryonic recessive lethal. Using surgical manipulations and analysis of gene expression patterns in developing wings, we demonstrate that the effects on eyespot morphology are due to changes in the epidermal response component of eyespot induction. Our analysis of morphology and of gene expression in mutant embryos shows that

Who reads Single Locus Affects Embryonic Segment Polarity and Multiple Aspects of an Adult Evolutionary Novelty?

Author

Suzanne V Saenko; Paul M Brakefield; Patrícia Beldade

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, c2003-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Research Square (ISSN 1741-7007)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)