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This review discusses the organization and functioning of hematopoietic stem cell (HSC) niches in bone marrow, highlighting the complex microenvironments that regulate HSCs. It covers the anatomy of these niches, the various cell types involved, and the mechanisms of HSC-niche interactions, including the roles of mesenchymal stem/stromal cells. The review also addresses niche aging, leukemic transformations, and current modeling efforts to study HSC niches in vitro.

Author

cmarevalo

Language

EN