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Persistence Length Changes Dramatically as RNA Folds by Caliskan, G.; Hyeon, C.; Perez-Salas, U.; Briber, R. M.; Woodson, S. A.; Thirumalai, D. is a scholarly article available to read on EtoBox.

What is Persistence Length Changes Dramatically as RNA Folds about?

We determine the persistence length, $l_p$, for a bacterial group I ribozyme as a function of concentration of monovalent and divalent cations by fitting the distance distribution functions $P(r)$ obtained from small angle X-ray scattering intensity data to the asymptotic form of the calculated $P_{WLC}(r)$ for a worm-like chain (WLC). The $l_p$ values change dramatically over a narrow range of \Mg concentration from $\sim$21 \AA in the unfolded state (\textbf{U}) to $\sim$10 \AA in the compact ($\mathrm{I_C}$) and native states. Variations in $l_p$ with increasing \Na concentration are more gradual. In accord with the predictions of polyelectrolyte theory we find $l_p \propto 1/ \kappa^2$ where $\kappa$ is the inverse Debye-screening length.

Author

Caliskan, G.; Hyeon, C.; Perez-Salas, U.; Briber, R. M.; Woodson, S. A.; Thirumalai, D.

Published

2005

Language

EN