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Can I read In Vivo Analysis of a Proprietary Glass-based Adhesive for Sternal Fixation and Stabilization Using Rabbit and Sheep Models on EtoBox?
In Vivo Analysis of a Proprietary Glass-based Adhesive for Sternal Fixation and Stabilization Using Rabbit and Sheep Models by Cina Mehrvar; Emily Deignan; Mark Hurtig; Gideon Cohen; Paul Zalzal; Oleg Safir; Adel Alhalawani; Marcello Papini; Mark R. Towler is a Engineering article available to read on EtoBox.
What is In Vivo Analysis of a Proprietary Glass-based Adhesive for Sternal Fixation and Stabilization Using Rabbit and Sheep Models about?
Wire cerclage remains the standard method of care for sternal fixation, following median sternotomy, despite being beset with complications. An emerging treatment option has been to augment the wires with an adhesive. A patented ionomeric glass (mole fraction: SiO~2~:0.48, ZnO:0.36, CaO:0.12, SrO:0.04) has been used to formulate GPC+, a glass polyalkenoate cement (GPC), by mixing it with poly(acrylic) acid (PAA) and de-ionized water. In a human cadaver study, this material, when applied with wire cerclage, was able to significantly reduce sternal instability. However, the material has yet to be tested in pertinent animal models. Here, after a series of physical and mechanical tests to confirm suitability of the experimental material for implantation, three samples of GPC+ were implanted in either the tibia or femur of three different rabbits, alongside sham defects, for two different time modalities. A further seven samples of GPC+ and one poly(methyl methacrylate) control (PMMA) were implanted in either the tibia or femur of two different sheep. The sheep containing the PMMA was sacrificed at 8 weeks and the other at 16 weeks, to evaluate time dependent biological response. Upon s
Who reads In Vivo Analysis of a Proprietary Glass-based Adhesive for Sternal Fixation and Stabilization Using Rabbit and Sheep Models?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Cina Mehrvar; Emily Deignan; Mark Hurtig; Gideon Cohen; Paul Zalzal; Oleg Safir; Adel Alhalawani; Marcello Papini; Mark R. Towler
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)