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Chemical Analysis of Bis(5-amidino-2-benzimidazolyl) Methane in the Arthritic Rat Knee Using Microdialysis and Microcolumn Liquid Chromatography by Robert L. St. Claire III; Kenneth R. Brouwer is a Engineering article available to read on EtoBox.

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## Abstract Microcolumn liquid chromatography and microdialysis were coupled together to study the distribution of an IV administered drug into the knee joint of a rat with acute arthritis. Dialysate from microdialysis probes located directly within the intraarticular region and in the surrounding muscle was delivered at a flow rate of 0.25 μL min^−1^ directly into a microcolumn LC system. A 0.5‐mm i.d. microcolumn and fluorescence detector were utilized. An __in vitro__ model was developed to estimate the drug concentration in the dialysate. Differences in drug distribution between the intra and extraarticular knee regions were detected, and the potential utility of this technique in the pharmacokinetic evaluation of site‐specific drugs was demonstrated.

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Author

Robert L. St. Claire III; Kenneth R. Brouwer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1040-7685)

Published

1991

Language

EN

Field

Engineering (Physical Sciences)