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Improvement of Peripheral Nerve Regeneration in Acellular Nerve Grafts with Local Release of Nerve Growth Factor by Hailong Yu; Jiang Peng; Quanyi Guo; Li Zhang; Zhi Li; Bin Zhao; Xiang Sui; Yu Wang; Wenjing Xu; Shibi Lu is a Medicine article available to read on EtoBox.
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## Abstract Previous studies have demonstrated the potential of growth factors in peripheral nerve regeneration. A method was developed for sustained delivery of nerve growth factor (NGF) for nerve repair with acellular nerve grafts to augment peripheral nerve regeneration. NGF‐containing polymeric microspheres were fixed with fibrin glue around chemically extracted acellular nerve grafts for prolonged, site‐specific delivery of NGF. A total of 52 Wister rats were randomly divided into four groups for treatment: autografting, NGF‐treated acellular grafting, acellular grafting alone, and acellular grafting with fibrin glue. The model of a 10‐mm sciatic nerve with a 10‐mm gap was used to assess nerve regeneration. At the 2nd week after nerve repair, the length of axonal regeneration was longer with NGF‐treated acellular grafting than acellular grafting alone and acellular grafting with fibrin glue, but shorter than autografting (__P__ < 0.05). Sixteen weeks after nerve repair, nerve regeneration was assessed functionally and histomorphometrically. The percentage tension of the triceps surae muscles in the autograft group was 85.33 ± 5.59%, significantly higher than that of NGF‐treate
Who reads Improvement of Peripheral Nerve Regeneration in Acellular Nerve Grafts with Local Release of Nerve Growth Factor?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hailong Yu; Jiang Peng; Quanyi Guo; Li Zhang; Zhi Li; Bin Zhao; Xiang Sui; Yu Wang; Wenjing Xu; Shibi Lu
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0738-1085)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)