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5′ ins/del and 3′ VNTR polymorphisms in the apolipoprotein B gene in relation to lipids and coronary artery disease by Lamia Rebhi; Asma Omezzine; Kaouther Kchok; Radhia Belkahla; Ibtihel Ben HadjMbarek; Jihen Rejeb; Nabila Ben Rejeb; Naoufel Nabli; Amina Bibi; Taieb Massoud; Ahmed Abdelaziz; Essia Boughzala; Ali Bouslama is a Medicine article available to read on EtoBox.
What is 5′ ins/del and 3′ VNTR polymorphisms in the apolipoprotein B gene in relation to lipids and coronary artery disease about?
## Background: Studies that considered apolipoprotein b (apob) gene polymorphisms as risk factors for coronary artery disease (cad) have reported conflicting results. we sought to analyze the association between 5' ins/del and 3' vntr polymorphisms of apob, lipid parameters and cad risk. ## Methods: We recruited 251 patients with cad, documented by coronary angiography, and 94 controls. genotyping was performed by pcr. lipids and apolipoproteins were measured. ## Results: 5' ins/del (ins/ins, ins/del, del/del) and 3' vntr (ll, ss, ls) polymorphism frequencies were significantly (p<0.05) different between controls and cad patients. ll and del/del were significantly associated with higher levels of apolipoprotein b (apob), total cholesterol/high-density lipoprotein cholesterol ratio and apob/apoa-i ratio (p<0.05) and with increased risk of cad. the odds ratio for significant coronary stenosis associated with del/del was 3.2 (95% ci 1.6-36.42) (p=0.032) and with ll was 2.2 (95% ci 1.1-5.1) (p=0.042). ## Conclusions: The two polymorphisms exert an impact on lipid levels and contribute to the susceptibility to the development of cad.
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- Author
- Lamia Rebhi; Asma Omezzine; Kaouther Kchok; Radhia Belkahla; Ibtihel Ben HadjMbarek; Jihen Rejeb; Nabila Ben Rejeb; Naoufel Nabli; Amina Bibi; Taieb Massoud; Ahmed Abdelaziz; Essia Boughzala; Ali Bouslama
- Publisher
- Walter de Gruyter GmbH & Co. KG; Walter de Gruyter GmbH (ISSN 1434-6621)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)