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Can I read N ‐Methyl‐ C ‐(trichlortitanio)formimidoylchlorid. Ein effizientes Reagenz zur Homologisierung von Aldehyden und Ketonen zu α‐Hydroxy‐carbonsäureamiden on EtoBox?
N ‐Methyl‐ C ‐(trichlortitanio)formimidoylchlorid. Ein effizientes Reagenz zur Homologisierung von Aldehyden und Ketonen zu α‐Hydroxy‐carbonsäureamiden by Martin Schiess; Dieter Seebach is a Chemistry article available to read on EtoBox.
What is N ‐Methyl‐ C ‐(trichlortitanio)formimidoylchlorid. Ein effizientes Reagenz zur Homologisierung von Aldehyden und Ketonen zu α‐Hydroxy‐carbonsäureamiden about?
**__N__‐Methyl‐__C__‐(trichlorotitanio)formimidoyl Chloride, a Highly Efficient Reagent for Homologations of Aldehydes and Ketones to α‐Hydroxycarboxamides** The known title compound **6** formed by addition of titanium tetrachloride to methyl isocyanide in methylene chloride adds to the carbonyl group of aldehydes and ketones. The adducts **7** are hydrolized to __N__‐methyl‐α‐hydroxycarboxamides **8** which are (from ketones) or are not branched (from aldehydes) in the α‐position. The yields in this new modification of the __Passerini__ reaction are near 90%, also with readily enolized ketones such as acetone and acetophenone. In contrast to the previously used organotitanium reagents of the type RTiX~3~, the preparation of the reagent **6** does not require any Li‐, Mg‐ or Zn‐derivative as a precusor.
Who reads N ‐Methyl‐ C ‐(trichlortitanio)formimidoylchlorid. Ein effizientes Reagenz zur Homologisierung von Aldehyden und Ketonen zu α‐Hydroxy‐carbonsäureamiden?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Martin Schiess; Dieter Seebach
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0018-019X)
- Published
- 1983
- Language
- DE
- Field
- Chemistry (Physical Sciences)