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A Simulation Study of the Number of Events per Variable in Logistic Regression Analysis by Peter Peduzzi; John Concato; Elizabeth Kemper; Theodore R. Holford; Alvan R. Feinstein is a Decision Sciences article available to read on EtoBox.

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We performed a Monte Carlo study to evaluate the effect of the number of events per variable (EPV) analyzed in logistic regression analysis. The simulations were based on data from a cardiac trial of 673 patients in which 252 deaths occurred and seven variables were cogent predictors of mortality; the number of events per predictive variable was ( 252 7 = 36) for the full sample. For the simulations, at values of EPV = 2, 5, 10, 15, 20, and 25, we randomly generated 500 samples of the 673 patients, chosen with replacement, according to a logistic model derived from the full sample. Simulation results for the regression coefficients for each variable in each group of 500 samples were compared for bias, precision, and significance testing against the results of the model fitted to the original sample. For EPV values of 10 or greater, no major problems occurred. For EPV values less than 10, however, the regression coefficients were biased in both positive and negative directions; the large sample variance estimates from the logistic model both overestimated and underestimated the sample variance of the regression coeffi-cients; the 90% confidence limits about the estimated values did

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Author

Peter Peduzzi; John Concato; Elizabeth Kemper; Theodore R. Holford; Alvan R. Feinstein

Publisher

Elsevier BV

Published

1996

Language

EN

Field

Decision Sciences (Social Sciences)