Opening book details…
Can I read “Altered-self” or “near-self” in the positive selection of lymphocyte repertoires? on EtoBox?
“Altered-self” or “near-self” in the positive selection of lymphocyte repertoires? by Donald R. Forsdyke is a Immunology and Microbiology article available to read on EtoBox.
What is “Altered-self” or “near-self” in the positive selection of lymphocyte repertoires? about?
Positive selection of lymphocyte repertoires is now recognized as applying to both B and T cells. However, much of the early literature on positive selection focussed on cell-mediated immunity (T cells), which biased consideration of its general biological role. The term "alteredself," which initially captured the idea of self (i.e. MHC) altered by the addition of what was later found to be a peptide fragment, has not proven robust and may now be clouding our understanding. It is recommended that the term "near-self" be reintroduced since it captures the essence of the probable underlying adaptive process-sub-threshold self-reactivity to countermand rapid pathogen mutation.
Who reads “Altered-self” or “near-self” in the positive selection of lymphocyte repertoires??
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Donald R. Forsdyke
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)
- Published
- 2005
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)