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Real-world association between systemic corticosteroid exposure and complications in US patients with severe asthma by Thomas B Casale; Thomas Corbridge; Guillaume Germain; François Laliberté; Sean D MacKnight; Julien Boudreau; Mei S Duh; Arijita Deb is a Medicine article available to read on EtoBox.
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## Background Systemic corticosteroid (SCS) use remains widespread among patients with severe asthma, despite associated complications. ## Objective Evaluate the association between cumulative SCS exposure and SCS-related complications in severe asthma. ## Methods This retrospective, longitudinal study used claims data from the Optum Clinformatics Data Mart database (GSK ID: 214469). Eligible patients (≥ 12 years old) had an asthma diagnosis and were divided into two cohorts: SCS use and non/burst-SCS use. Patients in the SCS use cohort had a claim for a daily prednisone-equivalent dose ≥ 5 mg SCS following ≥ 6 months of continuous SCS use; those in the non/burst-SCS cohort had no evidence of continuous SCS use and had a non-SCS controller/rescue medication initiation claim. For each cohort, the date of the qualifying claim was the index date. SCS users were further stratified by SCS use during each quarter of follow-up: low (≤ 6 mg/day), medium (> 6–12 mg/day), high (> 12 mg/day), and continuous high (≥ 20 mg/day for 90 days). SCS-related complications were evaluated in the quarter following SCS exposure. The adjusted odds ratios (OR) of experiencing SCS-related complications duri
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- Author
- Thomas B Casale; Thomas Corbridge; Guillaume Germain; François Laliberté; Sean D MacKnight; Julien Boudreau; Mei S Duh; Arijita Deb
- Publisher
- BioMed Central
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)