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Can I read Skeletal muscle ClC-1 chloride channels in health and diseases on EtoBox?
Skeletal muscle ClC-1 chloride channels in health and diseases by Concetta Altamura; Jean-Francois Desaphy; Diana Conte; Annamaria De Luca; Paola Imbrici is a Medicine article available to read on EtoBox.
What is Skeletal muscle ClC-1 chloride channels in health and diseases about?
In 1970, the study of the pathomechanisms underlying myotonia in muscle fibers isolated from myotonic goats highlighted the importance of chloride conductance for skeletal muscle function; 20 years later, the human ClC-1 chloride channel has been cloned; last year, the crystal structure of human protein has been solved. Over the years, the efforts of many researchers led to significant advances in acknowledging the role of ClC-1 in skeletal muscle physiology and the mechanisms through which ClC-1 dysfunctions lead to impaired muscle function. The wide spectrum of pathophysiological conditions associated with modification of ClC-1 activity, either as the primary cause, such as in myotonia congenita, or as a secondary adaptive mechanism in other neuromuscular diseases, supports the idea that ClC-1 is relevant to preserve not only for skeletal muscle excitability, but also for skeletal muscle adaptation to physiological or harmful events. Improving this understanding could open promising avenues toward the development of selective and safe drugs targeting ClC-1, with the aim to restore normal muscle function. This review summarizes the most relevant research on ClC-1 channel physiolog
Who reads Skeletal muscle ClC-1 chloride channels in health and diseases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Concetta Altamura; Jean-Francois Desaphy; Diana Conte; Annamaria De Luca; Paola Imbrici
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0031-6768)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Life Sciences)