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Syntheses and Cytotoxicities of Four Stereoisomers of Muricatacin from d -Glucose by Sung-Hwa Yoon; Ho-Sang Moon; Sung-Kwan Hwang; SeungRyong Choi; Suk-Ku Kang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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AbstractÐFour stereoisomers of muricatacin 1a±d were prepared by the reaction of corresponding aldehydes 4a±d, which in turn were prepared from d-glucose, with the anion of triethylphosphonoacetate followed by reduction and cyclization under acidic conditions. Cytotoxicities of four stereoisomers were tested against in vitro A-549 cell line as well as MCF-7 cell line. Stereochemistry at C 4 and C 5 position of muricatacin did not aect the cytotoxicities signi®cantly.

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Author

Sung-Hwa Yoon; Ho-Sang Moon; Sung-Kwan Hwang; SeungRyong Choi; Suk-Ku Kang

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)