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Biomimetic Extracellular Scaffolds by Microfluidic Superstructuring of Nanofibers by Jack Kolberg-Edelbrock; Thomas J. Cotey; Steven Y. Ma; Litsa M. Kapsalis; Delaney M. Bondoc; Sieun Ruth Lee; Hiroaki Sai; Cara S. Smith; Feng Chen; Alexandra N. Kolberg-Edelbrock; Madison E. Strong; Samuel I. Stupp is a Engineering article available to read on EtoBox.

What is Biomimetic Extracellular Scaffolds by Microfluidic Superstructuring of Nanofibers about?

The extracellular matrix is a dynamic framework bearing chemical and morphological cues that support many cellular functions, and artificial analogs with welldefined chemistry are of great interest for biomedical applications. Herein, we describe hierarchical, extracellular-matrix-mimetic microgels, termed "superbundles" (SBs) composed of peptide amphiphile (PA) supramolecular nanofiber networks created using flow-focusing microfluidic devices. We explore the effects of altered flow rate ratio and PA concentration on the ability to create SBs and develop design rules for producing SBs with both cationic and anionic PA nanofibers and gelators. We demonstrate the morphological similarities of SBs to decellularized extracellular matrices and showcase their ability to encapsulate and retain proteinaceous cargos with a wide variety of isoelectric points. Finally, we demonstrate that the novel SB morphology does not affect the well-established biocompatibility of PA gels.

Who reads Biomimetic Extracellular Scaffolds by Microfluidic Superstructuring of Nanofibers?

Author

Jack Kolberg-Edelbrock; Thomas J. Cotey; Steven Y. Ma; Litsa M. Kapsalis; Delaney M. Bondoc; Sieun Ruth Lee; Hiroaki Sai; Cara S. Smith; Feng Chen; Alexandra N. Kolberg-Edelbrock; Madison E. Strong; Samuel I. Stupp

Publisher

American Chemical Society (ACS)

Published

2023

Language

EN

Field

Engineering (Physical Sciences)