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Cutaneous involvement by angioimmunoblastic T-cell lymphoma with remarkable heterogeneous Epstein-Barr virus expression by Holly A. Brown; William R. Macon; Paul J. Kurtin; Lawrence E. Gibson is a Medicine article available to read on EtoBox.

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**Introduction:** Initially described as an abnormal immune reaction, most cases of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)‐like T‐cell infiltrates are now regarded as a peripheral T‐cell lymphoma (AILD T‐NHL). AILD T‐NHL is characterized clinically with constitutional symptoms, generalized lymphadenopathy, hepatosplenomegaly, skin rash, and polyclonal hypergammaglobulinemia. Epstein‐Barr virus (EBV) is frequently detected in involved lymph nodes, but the presence of EBV in cutaneous infiltrates of AILD T‐NHL has rarely been examined. We present a patient with AILD T‐NHL with cutaneous involvement that shows marked heterogeneity of EBV expression in the lymph node and skin biopsies, and review the histological findings of AILD T‐NHL in the skin. **Methods:** Two skin biopsies of a diffuse maculopapular rash and a lymph node were examined and immunophenotyped. __In situ__ hybridization for detection of EBV in the lymph node and skin biopsies was utilized. In order to attempt to delineate which lymphocytes were EBV positive, skin biopsies were dual labeled with CD3, CD45RO, CD20 and EBV. The skin biopsies and lymph node were submitted for gene rearrangement stud

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Author

Holly A. Brown; William R. Macon; Paul J. Kurtin; Lawrence E. Gibson

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0303-6987)

Published

2001

Language

EN

Field

Medicine (Health Sciences)