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Preoperative or Postoperative Therapy for Stage II or III Rectal Cancer: An Updated Practice Guideline by R.K.S. Wong; S. Berry; K. Spithoff; M. Simunovic; K. Chan; O. Agboola; B. Dingle is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Preoperative or Postoperative Therapy for Stage II or III Rectal Cancer: An Updated Practice Guideline about?

Aims: Uncertainty remains regarding the optimal therapy for patients with stage II or III rectal cancer. Systematic reviews and practice guidelines on preoperative and postoperative therapy for rectal cancer were published by the Gastrointestinal Cancer Disease Site Group in 2003 and 2000, respectively. The systematic reviews were updated and revised and new recommendations for preoperative and postoperative therapy were developed based on the updated body of evidence. The following research questions were addressed: After appropriate preoperative staging tests, should patients with resectable clinical stage II or III rectal cancer be offered preoperative radiotherapy (with or without chemotherapy)? What is the role of postoperative radiotherapy and/or chemotherapy for patients with resected stage II or III rectal cancer who have not received preoperative radiotherapy, in terms of improving survival and delaying local recurrence? Materials and methods: The MEDLINE, EMBASE and Cochrane Library databases, as well as meeting proceedings from the American Society of Clinical Oncology, were searched for reports of randomised controlled trials and meta-analyses comparing preoperative or

Who reads Preoperative or Postoperative Therapy for Stage II or III Rectal Cancer: An Updated Practice Guideline?

Author

R.K.S. Wong; S. Berry; K. Spithoff; M. Simunovic; K. Chan; O. Agboola; B. Dingle

Publisher

Elsevier Science; Springer; Elsevier ; Springer-Verlag; W. B. Saunders Co., Ltd.; Springer Verlag; Elsevier BV; Springer Science and Business Media LLC (ISSN 1433-2981)

Published

2010

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)