Can I read BLIAM: Literature-based Data Synthesis for Synergistic Drug Combination Prediction on EtoBox?

BLIAM: Literature-based Data Synthesis for Synergistic Drug Combination Prediction by Yang, Cai; Woicik, Addie; Poon, Hoifung; Wang, Sheng is a scholarly article available to read on EtoBox.

What is BLIAM: Literature-based Data Synthesis for Synergistic Drug Combination Prediction about?

Language models pre-trained on scientific literature corpora have substantially advanced scientific discovery by offering high-quality feature representations for downstream applications. However, these features are often not interpretable, and thus can reveal limited insights to domain experts. Instead of obtaining features from language models, we propose BLIAM, a literature-based data synthesis approach to directly generate training data points that are interpretable and model-agnostic to downstream applications. The key idea of BLIAM is to create prompts using existing training data and then use these prompts to synthesize new data points. BLIAM performs these two steps iteratively as new data points will define more informative prompts and new prompts will in turn synthesize more accurate data points. Notably, literature-based data augmentation might introduce data leakage since labels of test data points in downstream applications might have already been mentioned in the language model corpus. To prevent such leakage, we introduce GDSC-combo, a large-scale drug combination discovery dataset that was published after the biomedical language model was trained. We found that BLIA

Author

Yang, Cai; Woicik, Addie; Poon, Hoifung; Wang, Sheng

Published

2023

Language

EN