Can I read Long-term Results of Adjuvant Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients on EtoBox?

Long-term Results of Adjuvant Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients by Cécile Ortholan; Jean-Michel Hannoun-Lévi; Jean-Marc Ferrero; Rémy Largillier; Adel Courdi is a Medicine article available to read on EtoBox.

What is Long-term Results of Adjuvant Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients about?

Purpose: To evaluate early and late reactions, local control, disease-free survival, cause-specific survival, and overall survival of elderly breast cancer patients treated with adjuvant once-weekly hypofractionated radiotherapy (RT). Methods and Materials: Between 1987 and 1999, 150 patients (median age, 78 years) who presented with 151 nonmetastatic breast tumors were treated with surgery and then adjuvant hypofractionated RT. The clinical stage distribution was as follows: T1 in 47.7%, T2 in 43.2%, T3 in 6.1%, and T4 in 3.0%. Axillary lymph nodes were positive in 33.8% of cases. Estrogen receptors were present in 89.9%, and progesterone receptors in 77.3%. Conservative breast surgery was performed in 71.5% and total mastectomy in 28.5%. RT was delivered once weekly in five fractions of 6.5 Gy to a total dose of 32.5 Gy. A boost was delivered to the tumor bed in 33.1%. Adjuvant hormonal therapy was given in 76.2% of patients. The median follow-up was 65 months. Results: The Kaplan-Meier rate of all grades of early skin reactions was 26.5%, and the rate of all late reactions was 45.5%, mainly Grades 1 and 2. Early and late reactions were greater in those who underwent boost RT. Th

Who reads Long-term Results of Adjuvant Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients?

Author

Cécile Ortholan; Jean-Michel Hannoun-Lévi; Jean-Marc Ferrero; Rémy Largillier; Adel Courdi

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2005

Language

EN

Field

Medicine (Health Sciences)