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Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s disease by Edward N. Wilson; Christina B. Young; Javier Ramos Benitez; Michelle S. Swarovski; Igor Feinstein; Manu Vandijck; Yann Le Guen; Nandita M. Kasireddy; Marian Shahid; Nicole K. Corso; Qian Wang; Gabriel Kennedy; Alexandra N. Trelle; Betty Lind; Divya Channappa; Malia Belnap; Veronica Ramirez; Irina Skylar-Scott; Kyan Younes; Maya V. Yutsis; Nathalie Le Bastard; Joseph F. Quinn; Christopher H. van Dyck; Angus Nairn; Carolyn A. Fredericks; Lu Tian; Geoffrey A. Kerchner; Thomas J. Montine; Sharon J. Sha; Guido Davidzon; Victor W. Henderson; Frank M. Longo; Michael D. Greicius; Anthony D. Wagner; Tony Wyss-Coray; Kathleen L. Poston; Elizabeth C. Mormino; Katrin I. Andreasson is a Medicine article available to read on EtoBox.
What is Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s disease about?
## Abstract ## Background The recent promise of disease-modifying therapies for Alzheimer’s disease (AD) has reinforced the need for accurate biomarkers for early disease detection, diagnosis and treatment monitoring. Advances in the development of novel blood-based biomarkers for AD have revealed that plasma levels of tau phosphorylated at various residues are specific and sensitive to AD dementia. However, the currently available tests have shortcomings in access, throughput, and scalability that limit widespread implementation. ## Methods We evaluated the diagnostic and prognostic performance of a high-throughput and fully-automated Lumipulse plasma p-tau181 assay for the detection of AD. Plasma from older clinically unimpaired individuals (CU, n = 463) and patients with mild cognitive impairment (MCI, n = 107) or AD dementia (n = 78) were obtained from the longitudinal Stanford University Alzheimer’s Disease Research Center (ADRC) and the Stanford Aging and Memory Study (SAMS) cohorts. We evaluated the discriminative accuracy of plasma p-tau181 for clinical AD diagnosis, association with amyloid β peptides and p-tau181 concentrations in CSF, association with amyloid positron em
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- Author
- Edward N. Wilson; Christina B. Young; Javier Ramos Benitez; Michelle S. Swarovski; Igor Feinstein; Manu Vandijck; Yann Le Guen; Nandita M. Kasireddy; Marian Shahid; Nicole K. Corso; Qian Wang; Gabriel Kennedy; Alexandra N. Trelle; Betty Lind; Divya Channappa; Malia Belnap; Veronica Ramirez; Irina Skylar-Scott; Kyan Younes; Maya V. Yutsis; Nathalie Le Bastard; Joseph F. Quinn; Christopher H. van Dyck; Angus Nairn; Carolyn A. Fredericks; Lu Tian; Geoffrey A. Kerchner; Thomas J. Montine; Sharon J. Sha; Guido Davidzon; Victor W. Henderson; Frank M. Longo; Michael D. Greicius; Anthony D. Wagner; Tony Wyss-Coray; Kathleen L. Poston; Elizabeth C. Mormino; Katrin I. Andreasson
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)