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Bone potential heterogeneity in hBMSCs is associated with their immunomodulatory capacity by Raddi, Najat; Coquelin, Laura; Vidal, Luciano; Zazou, Sanae; Windels, Gabriel; Mebarki, Miryam; Manassero, Mathieu; Rouard, Hélà̈ne; Chevallier, Nathalie is a Medicine article available to read on EtoBox.
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prostheses. Utilization of additive manufacturing (3D-printing) to incorporate porous lattice structures in CoCr implants to enhance bone-implant interface is rarely reported and therefore investigated in this study. Methodology: 16-weeks-old female rabbits were randomly divided into 3 groups: control (Porosity=0), group A (Porosity=0.25) and group B (Porosity=0.55) at n=3 per group. A 5-mm defect was drilled on the patellofemoral groove and 3D-printed CoCr implants were implanted (Figure 1). Ex vivo radiography and non-decalcified histology were performed at end-point of week 8. Bone-implant interface and bone in-growth were evaluated by histomorphometry. ANOVA was used to detect difference between groups with post-hoc Bonferroni test considered at pb 0.05. Results: Bone in-growth were observed in small and large lattice unit group and both with higher bone-implant interface at 918.5 ± 40.3 μm and 590.5 ± 105.4 μm, respectively versus the control group at 218 ± 4.2 μm. Histomorphometry evaluation also showed that group A and B had 1.9 times and 5.2 times higher osteoid area fraction, respectively, compared with the control group. Discussion and conclusion: Larger lattice units wit
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- Author
- Raddi, Najat; Coquelin, Laura; Vidal, Luciano; Zazou, Sanae; Windels, Gabriel; Mebarki, Miryam; Manassero, Mathieu; Rouard, Hélà̈ne; Chevallier, Nathalie
- Publisher
- Elsevier ; Elsevier Inc.; New York: Elsevier; Elsevier BV (ISSN 2352-1872)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)