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Synthesis and Antimicrobial Study of Novel Heterocyclic Compounds from Hydroxybenzophenones by Shaukath A. Khanum; Sheena Shashikanth; S. Umesha; R. Kavitha is a Chemistry article available to read on EtoBox.

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The triazolothiadiazine analogues 6a-e were obtained via a multistep synthesis sequences beginning with the hydroxybenzophenones 1a-e. Hydroxybenzophenones on reaction with ethyl chloroacetate affords ethyl (2-aroylaryloxy)acetates 2a-e which on treatment with hydrazine hydrate yields 2-(2-aroylaryloxy)acetohydrazides 3a-e. Intramolecular cyclization of 3a-e with carbon disulfide affords 5-(2aroylaryloxy)methyl-1,3,4-oxadiazole-2-(3H)thiones 4a-e, which on treatment with hydrazine hydrate yields 4-amino-5-(2-aroyl aryloxy)methyl-1,2,4-triazole-3-(2H)thiones 5a-e. Condensation of 5a-e with a-halocarbonyl compound results in 3-(2-aroylaryloxy)methyl-6-phenyl-1,2,4-triazolo [3,4-b][1,3,4] thiadiazine 6a-e analogues. The compounds 4a-e, 5a-e and 6a-e were tested against variety of fungal and bacterial strains in comparison to fluconazole and chloramphenicol, respectively.

Who reads Synthesis and Antimicrobial Study of Novel Heterocyclic Compounds from Hydroxybenzophenones?

Author

Shaukath A. Khanum; Sheena Shashikanth; S. Umesha; R. Kavitha

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)

Published

2005

Language

EN

Field

Chemistry (Physical Sciences)