Can I read Regulating P73 Isoforms in Human Tumours on EtoBox?

Regulating P73 Isoforms in Human Tumours by PJ Coates is a Medicine article available to read on EtoBox.

What is Regulating P73 Isoforms in Human Tumours about?

## Abstract Although mutations in the __TP73__ gene are extremely rare in human tumours, altered expression is common. In some tumours, most notably leukaemias and lymphomas, expression of __TP73__ is reduced, suggesting a tumour suppressor role. In contrast, __TP73__ is over‐expressed in many other tumour types, implying that it has oncogenic functions in human tumourigenesis. These conflicting scenarios can be reconciled by the observations that the __TP73__ gene produces p53‐like isoforms (TAp73) and anti‐p53 isoforms (ΔTAp73). Thus, loss of TAp73 or over‐expression of ΔTAp73 should each promote oncogenic transformation, and the balance of expression of the opposing isoforms is the crucial factor. The mechanisms that regulate expression of TP73 isoforms are therefore of great interest. Recent data provide evidence for interacting roles of ZEB1, p300, and a polymorphic 73 bp deletion in intron 1 of the human __TP73__ gene in this process. Importantly, alterations to the proposed regulatory pathway for controlling TP73 isoform expression in colorectal cancer are associated with adverse clinico‐pathological characteristics. Because p73 is also associated with tumour chemosensitivit

Who reads Regulating P73 Isoforms in Human Tumours?

Author

PJ Coates

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2006

Language

EN

Field

Medicine (Health Sciences)