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Combination Antibiotic Therapy Versus Monotherapy in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: an Open-label Randomized Trial by Phuong Nguyen Thi Thu; Minh Ngo Thị Huong; Ngan Tran Thi; Hoi Nguyen Thanh; Khue Pham Minh is a Medicine article available to read on EtoBox.
What is Combination Antibiotic Therapy Versus Monotherapy in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: an Open-label Randomized Trial about?
## Abstract ## Background The role of antibiotics in the treatment of chronic obstructive pulmonary disease (COPD) exacerbations and their effectiveness in combination have not been clearly established. To determine whether using a combination of fluoroquinolones and beta-lactams improves the clinical and microbiological efficacy of antibiotics on day 20 of treatment, we conducted an open-label randomized trial based on clinical outcomes, microbiological clearance, spirometry tests, and signs of systemic inflammation in patients hospitalized with acute exacerbations of COPD. ## Methods We enrolled 139 subjects with COPD exacerbations, defined as acute worsening of respiratory symptoms leading to additional treatment. Patients were divided randomly into two groups: 79 patients using beta-lactam antibiotics alone and 60 using beta-lactam antibiotics plus fluoroquinolones. Clinical and microbiological responses, spirometry tests, symptom scores, and serum C-reactive protein (CRP) levels were evaluated. ## Results Clinical success, lung function, and symptoms were similar in patients with or without fluoroquinolone administration on days 10 and 20. Combination therapy was superior in t
Who reads Combination Antibiotic Therapy Versus Monotherapy in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: an Open-label Randomized Trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Phuong Nguyen Thi Thu; Minh Ngo Thị Huong; Ngan Tran Thi; Hoi Nguyen Thanh; Khue Pham Minh
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)