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Association of Immune Cell Subsets with Incident Heart Failure in Two Population‐based Cohorts by Arjun Sinha; Colleen M. Sitlani; Margaret F. Doyle; Alison E. Fohner; Petra Buzkova; James S. Floyd; Sally A. Huber; Nels C. Olson; Joyce N. Njoroge; Jorge R. Kizer; Joseph A. Delaney; Sanjiv S. Shah; Russell P. Tracy; Bruce Psaty; Matthew Feinstein is a Medicine article available to read on EtoBox.
What is Association of Immune Cell Subsets with Incident Heart Failure in Two Population‐based Cohorts about?
## Abstract ## Aims Circulating inflammatory markers are associated with incident heart failure (HF), but prospective data on associations of immune cell subsets with incident HF are lacking. We determined the associations of immune cell subsets with incident HF as well as HF subtypes [with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF)]. ## Methods and results Peripheral blood immune cell subsets were measured in adults from the Multi‐Ethnic Study of Atherosclerosis (MESA) and Cardiovascular Health Study (CHS). Cox proportional hazard models adjusted for demographics, HF risk factors, and cytomegalovirus serostatus were used to evaluate the association of the immune cell subsets with incident HF. The average age of the MESA cohort at the time of immune cell measurements was 63.0 ± 10.4 years with 51% women, and in the CHS cohort, it was 79.6 ± 4.4 years with 62% women. In the meta‐analysis of CHS and MESA, a higher proportion of CD4+ T helper (Th) 1 cells (per one standard deviation) was associated with a lower risk of incident HF [hazard ratio (HR) 0.91, (95% CI 0.83–0.99), __P__ = 0.03]. Specifically, higher proportion of CD4+ Th1 cells was significant
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- Author
- Arjun Sinha; Colleen M. Sitlani; Margaret F. Doyle; Alison E. Fohner; Petra Buzkova; James S. Floyd; Sally A. Huber; Nels C. Olson; Joyce N. Njoroge; Jorge R. Kizer; Joseph A. Delaney; Sanjiv S. Shah; Russell P. Tracy; Bruce Psaty; Matthew Feinstein
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)