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Molecular Mechanism of Resveratrol’s Lipid Membrane Protection by Qinqin Fei; David Kent; Wesley M. Botello-Smith; Fariah Nur; Saadia Nur; Abdelaziz Alsamarah; Payal Chatterjee; Maria Lambros; Yun Luo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Resveratrol, a natural compound found in red wine and various vegetables, has drawn increasing interest due to its reported benefit in cardiovascular protection, neurodegenerative disorders, and cancer therapy. The mechanism by which resveratrol exerts such pleiotropic effects remains unclear. It remains as one of the most discussed polyphenol compounds in the debating "French Paradox". In this study, using molecular dynamics simulations of dipalmitoyl phosphatidylcholine (DPPC) bilayer with resveratrol, we generated a free energy map of resveratrol’s location and orientation of inside the lipid bilayer. We found that resveratrol increases the surface area per lipid and decreases membrane thickness, which is the opposite effect of the well-studied cholesterol on liquid phase DPPC. Most importantly, based on the simulation observation that resveratrol has a high probability of forming hydrogen bonds with __sn-1__ and __sn-2__ ester groups, we discovered a new mechanism using experimental approach, in which resveratrol protects both __sn-1__ and __sn-2__ ester bonds of DPPC and distearoyl phosphatidylcholine (DSPC) from phospholipase A1 (PLA1) and phospholipase A2 (PLA2)

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Author

Qinqin Fei; David Kent; Wesley M. Botello-Smith; Fariah Nur; Saadia Nur; Abdelaziz Alsamarah; Payal Chatterjee; Maria Lambros; Yun Luo

Publisher

Springer Science and Business Media LLC

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)