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Digital Design and Automated Fabrication of Bespoke Collagen Microfiber Scaffolds by Nicholas J. Kaiser; Jessica A. Bellows; Rajeev J. Kant; Kareen L.K. Coulombe is a Medicine article available to read on EtoBox.

What is Digital Design and Automated Fabrication of Bespoke Collagen Microfiber Scaffolds about?

A great variety of natural and synthetic polymer materials have been utilized in soft tissue engineering as extracellular matrix (ECM) materials. Natural polymers, such as collagen and fibrin hydrogels, have experienced especially broad adoption due to the high density of cell adhesion sites compared to their synthetic counterparts, ready availability, and ease of use. However, these and other hydrogels lack the structural and mechanical anisotropy that define the ECM in many tissues, such as skeletal and cardiac muscle, tendon, and cartilage. Herein, we present a facile, low-cost, and automated method of preparing collagen microfibers, organizing these fibers into precisely controlled mesh designs, and embedding these meshes in a bulk hydrogel, creating a composite biomaterial suitable for a wide variety of tissue engineering and regenerative medicine applications. With the assistance of custom software tools described herein, mesh patterns are designed by a digital graphical user interface and translated into protocols that are executed by a custom mesh collection and organization device. We demonstrate a high degree of precision and reproducibility in both fiber and mesh fabrica

Who reads Digital Design and Automated Fabrication of Bespoke Collagen Microfiber Scaffolds?

Author

Nicholas J. Kaiser; Jessica A. Bellows; Rajeev J. Kant; Kareen L.K. Coulombe

Published

2019

Language

EN

Field

Medicine (Health Sciences)