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The Global Transcriptomic Signature in Sinonasal Tissues Reveals Roles for Tissue Type and Chronic Rhinosinusitis Disease Phenotype by Bassiouni, A.; Ou, J.; Schreiber, A.; Geoghegan, J.; Tsykin, A.; Psaltis, A.J.; Wormald, P.-J.; Vreugde, S. is a Medicine article available to read on EtoBox.
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## Background: Rna sequencing (rna-seq) allows the characterization of a global transcriptomic signature in a least-biased fashion, but few studies have applied this method to investigate the pathophysiology of crs. ## Methods: We collected mucosal tissue samples from 6 crs without nasal polyps (crssnp), 6 crs with nasal polyps (crswnp), and 6 control patients. additional matched polyp samples were collected from the 6 crswnp patients. rna was extracted and sequenced on the illumina hiseq-2500. differential gene expression and pathway analyses were performed. ## Results: Crssnp showed evidence of upregulated interferon-mediated immunity, mhc-class-i mediated antigen presentation, cxcr3 binding, neutrophil chemotaxis and degranulation, and potential downregulation of genes related to cilia movement and production. crswnp polyp tissue showed upregulation of b-cell mediated immune responses, but reduced expression of genes related to epithelial morphogenesis and haemostasis. polyps also showed a generalized reduction of positive gene regulation. the sinonasal transcriptomic signature was largely determined by tissue type (polyp versus mucosa) and disease phenotype, with minimal signal
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- Author
- Bassiouni, A.; Ou, J.; Schreiber, A.; Geoghegan, J.; Tsykin, A.; Psaltis, A.J.; Wormald, P.-J.; Vreugde, S.
- Publisher
- Rhinology; International Rhinologic Society (ISSN 0300-0729)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)