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Can I read Lineage-specific Regulation of Cell Cycle Control Gene Expression During Haematopoietic Cell Differentiation on EtoBox?
Lineage-specific Regulation of Cell Cycle Control Gene Expression During Haematopoietic Cell Differentiation by Yusuke Furukawa; Jiro Kikuchi; Mitsuru Nakamura; Satsuki Iwase; Hisashi Yamada; Michio Matsuda is a Medicine article available to read on EtoBox.
What is Lineage-specific Regulation of Cell Cycle Control Gene Expression During Haematopoietic Cell Differentiation about?
To maintain the fidelity and integrity of blood formation, the cell cycle is under strict regulation during haematopoietic cell differentiation. To elucidate the molecular mechanisms of cell cycle regulation during haematopoiesis, we examined cell cycle control gene expression during lineage‐specific differentiation from CD34^+^ progenitor cells. Expression of cyclin‐dependent kinases (cdks) and cyclins, except __cdk4__, was generally suppressed in CD34^+^ cells freshly isolated from the bone marrow of healthy volunteers. Among four major cdk inhibitors, __p16__ was expressed more highly in CD34^+^ cells than in CD34‐negative bone marrow mononuclear cells, whereas the amounts of __p21__ and __p27__ transcripts increased in the CD34^−^ population. The behaviour of cell cycle control genes during haematopoietic differentiation was classified into four patterns: (i) universal upregulation (__cdc2__, __cdk2__, __cyclin A, cyclin B__ and __p21__); (ii) upregulation in specific lineages (__cyclin D1__, __cyclin D3__ and __p15__); (iii) no induction or stable expression (__cdk4__, __cyclin D2__, __cyclin E__ and __p27__); and (iv) universal downregulation (__p16__). Lineage‐specific chang
Who reads Lineage-specific Regulation of Cell Cycle Control Gene Expression During Haematopoietic Cell Differentiation?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yusuke Furukawa; Jiro Kikuchi; Mitsuru Nakamura; Satsuki Iwase; Hisashi Yamada; Michio Matsuda
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)