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Human Amnion Membrane Matrix as a Substratum for Axonal Regeneration in the Central Nervous System by F. H. Gage; S. N. Blaker; G. E. Davis; E. Engvall; S. Varon; M. Manthorpe is a Neuroscience article available to read on EtoBox.

What is Human Amnion Membrane Matrix as a Substratum for Axonal Regeneration in the Central Nervous System about?

Human Amnion Membrane Matrix (HAMM) was used as a substratum for the regeneration of neuronal axons in the central nervous system. A large piece of HAMM was bound to nitrocellulose paper (NCP) as a supporting material, and cut into small strips. Aspirative lesions of the fimbria-fornix were made in adult rats leaving a cavity separating the septum from the hippocampus. In the same operation a small piece of HAMM-NCP was placed into the cavity with one end abutting the axotomized septum and the other end abutting the denervated hippocampus. At times between 2 weeks and 3 months after surgery the brains of the animals were examined histologically for 1) host response to the implant; 2) maintenance of HAMM-NCP in the originally implanted orientation; 3) growth of acetylcholinesterase (AChE)-positive fibers on the HAMM; 4) growth of the AChE-positive fibers into the denervated hippocampus; and 5) non-neuronal cells on the HAMM. The NCP remained in place over the 3-month period. In most cases the HAMM and NCP remained apposed and caused no greater reaction in the brain beyond that created in response to the aspirative lesion alone. AChE-positive fibers grew out from the septum onto the

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Author

F. H. Gage; S. N. Blaker; G. E. Davis; E. Engvall; S. Varon; M. Manthorpe

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0014-4819)

Published

1987

Language

EN

Field

Neuroscience (Life Sciences)