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Can I read Synthesis of the vancomycin CDE ring system on EtoBox?
Synthesis of the vancomycin CDE ring system by Dale L. Boger; Richard T. Beresis; Olivier Loiseleur; Jason H. Wu; Steven L. Castle is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis of the vancomycin CDE ring system about?
A first generation synthesis of 22 is described constituting the first disclosure of the preparation of an appropriately protected and fully functionalized vancomycin CDE ring system complete with the C and E ring monochloro substitution pattern. The approach, which is based on two aromatic nucleophilic substitution reactions for sequential CD and DE macrocyclization, provided the opportunity to define an indirect solution to the control of the CDE atropisomer stereochemistry through selective thermal equilibration of the DE versus unaltered CD ring system. Its success provides a rationale for a preferred order to the CD and DE ring system introductions.
Who reads Synthesis of the vancomycin CDE ring system?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dale L. Boger; Richard T. Beresis; Olivier Loiseleur; Jason H. Wu; Steven L. Castle
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)