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Can I read Differentiation of Two Geometric Isomers of the Pharmaceutical Eprosartan Using Atmospheric Pressure Chemical Ionization on EtoBox?
Differentiation of Two Geometric Isomers of the Pharmaceutical Eprosartan Using Atmospheric Pressure Chemical Ionization by Jeffrey Brum; Robert Hannah is a Chemistry article available to read on EtoBox.
What is Differentiation of Two Geometric Isomers of the Pharmaceutical Eprosartan Using Atmospheric Pressure Chemical Ionization about?
The utility of an atmospheric pressure chemical ionization interface for distinguishing stereoisomers has been demonstrated. Two geometrical isomers of the pharmaceutical eprosartan ((E,Z)-3-[butyl-1-(4-carboxybenzyl)-1H-imidazole-5-yl]-2-[2-thienyl)methyl]propenoic acid) were investigated in the positiveand negative-ion modes with in-source collision-induced dissociation (CID). In positive-ion mode, CID spectra display significant differences between the two isomers. Under identical collisional conditions several fragment ions present in the CID spectrum of the E isomer (SK&F 108566) are significantly suppressed in the spectrum of the Z isomer (SB 206328). Analysis of the fragmentation patterns of both isomers indicates that a pathway initiated by the loss of neutral thiophene from the E isomer is inhibited in the CID spectra of the Z isomer. In negative-ion mode, fragmentation and corresponding differences in spectra are not observed. Fragmentation is observed to result primarily from the ionization process.
Who reads Differentiation of Two Geometric Isomers of the Pharmaceutical Eprosartan Using Atmospheric Pressure Chemical Ionization?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Jeffrey Brum; Robert Hannah
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-4198)
- Published
- 1997
- Language
- EN
- Field
- Chemistry (Physical Sciences)