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Sleep apnea: Altered brain connectivity underlying a working-memory challenge by Nicola Canessa; Vincenza Castronovo; Stefano F. Cappa; Sara Marelli; Antonella Iadanza; Andrea Falini; Luigi Ferini-Strambi is a Medicine article available to read on EtoBox.

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Obstructive sleep apnea (OSA) is characterized by the frequent presence of neuro-cognitive impairment. Recent studies associate cognitive dysfunction with altered resting-state brain connectivity between key nodes of the executive and default-mode networks, two anti-correlated functional networks whose strength of activation increases or decreases with cognitive activity, respectively. To date no study has investigated a relationship between cognitive impairment in OSA and brain connectivity during an __active__ working-memory challenge. We thus investigated the effect of OSA on working-memory performance and underlying brain connectivity. OSA patients and matched healthy controls underwent functional magnetic resonance imaging (__f__MRI) scanning while performing a 2-back working-memory task. Standard __f__MRI analyses highlighted the brain regions activated at increasing levels of working-memory load, which were used as seeds in connectivity analyses. The latter were based on a multiregional Psycho-Physiological-Interaction (PPI) approach, to unveil group differences in effective connectivity underlying working-memory performance. Compared with controls, in OSA patients normal wo

Who reads Sleep apnea: Altered brain connectivity underlying a working-memory challenge?

Author

Nicola Canessa; Vincenza Castronovo; Stefano F. Cappa; Sara Marelli; Antonella Iadanza; Andrea Falini; Luigi Ferini-Strambi

Publisher

Elsevier BV

Published

2018

Language

EN

Field

Medicine (Health Sciences)