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IgE-Mediated Asthma and Rhinitis I: A Role of Allergen Exposure? by Gunnar D. Nielsen; Jitka S. Hansen; Rikke M. Lund; Mette Bergqvist; Søren T. Larsen; Susanne K. Clausen; Peter Thygesen; Otto M. Poulsen is a Medicine article available to read on EtoBox.

What is IgE-Mediated Asthma and Rhinitis I: A Role of Allergen Exposure? about?

Exposures to airborne protein antigens, aeroallergens, may cause sensitization with production of Th2-dependent antibodies, including IgE. The IgE antibodies and associated cellular responses are responsible for the allergic airway diseases, allergic rhinitis and allergic asthma, which are increasing in societies with Western life style. Aeroallergens may have different potential to sensitize exposed subjects. Thus, there are only a limited number of important groups of aeroallergens, which are those from house dust mites, cockroaches, pets, pollens, and moulds. Allergy follows to a certain extent the pharmacological/toxicological paradigm of dose-response relationship. Unlike effects of pharmacologically and toxicologically active substances, allergens elicit their adverse effects in a two-stage process. In the first stage the immunologically naïve individual is sensitized to the allergen. In the second stage renewed exposure to the allergen elicits the disease response. Also, high concentrations of aeroallergens may induce immunological tolerance. The scientific literature suggests that many environmental factors contribute to the increase in sensitization and development of airw

Who reads IgE-Mediated Asthma and Rhinitis I: A Role of Allergen Exposure??

Author

Gunnar D. Nielsen; Jitka S. Hansen; Rikke M. Lund; Mette Bergqvist; Søren T. Larsen; Susanne K. Clausen; Peter Thygesen; Otto M. Poulsen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0901-9928)

Published

2002

Language

EN

Field

Medicine (Life Sciences)