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Stereotactically Guided Conformal Radiotherapy for Progressive Low-grade Gliomas of Childhood by Frank H Saran; Brigitta G Baumert; Vincent S Khoo; Elizabeth J Adams; Maria L Garré; Alan P Warrington; Michael Brada is a Medicine article available to read on EtoBox.
What is Stereotactically Guided Conformal Radiotherapy for Progressive Low-grade Gliomas of Childhood about?
Purpose: To describe the rationale, technique, and early results of stereotactically guided conformal radiotherapy (SCRT) in the treatment of progressive or inoperable low-grade gliomas (LGGs) of childhood. Methods and Materials: Between September 1994 and May 1999, 14 children (median age 6 years, range 5-16) with LGG were treated with SCRT at the Royal Marsden NHS Trust. Tumors were located at the optic chiasm (n ؍ 9), third ventricle (n ؍ 2), hypothalamus, craniocervical junction, and pineal region (each n ؍ 1). Four patients received chemotherapy before SCRT. Immobilization was in a Gill-Thomas-Cosman frame (n ؍ 12) and subsequently in a specially designed pediatric version of the frame (n ؍ 2). Stereotactic coordinates and the tumor were defined by CT scanning with a fiducial system and MRI fusion. The median tumor volume was 19.5 cm 3 (range 7.5-180). The planning target volume was defined as the area of enhancing tumor plus a 5-10-mm margin. The treatment technique consisted of 4 isocentric, noncoplanar, conformal, fixed fields. Treatment was delivered in 30 -33 daily fractions to a total dose of 50 -55 Gy. Results: SCRT was well tolerated, with transient hair loss
Who reads Stereotactically Guided Conformal Radiotherapy for Progressive Low-grade Gliomas of Childhood?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Frank H Saran; Brigitta G Baumert; Vincent S Khoo; Elizabeth J Adams; Maria L Garré; Alan P Warrington; Michael Brada
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)