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Determination of dissociation constants of 99mTechnetium radiopharmaceuticals by capillary electrophoresis by R Jankowsky; M Friebe; B Noll; B Johannsen is a Chemistry article available to read on EtoBox.

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99m Capillary electrophoresis was applied to investigate pK values of Tc radiotracers used in nuclear medicine. Therefore, a 99m 99m 99m the protonation equilibria of the carboxyl groups of Tc-mercaptoacetylglycylglycylglycine ( Tc-MAG ) and Tc-3 99m 99m ethylenecysteine dimer ( Tc-EC) were studied by pH-dependent determination of electrophoretical velocities. Tc-99m ethylenecysteine dimer diethyl ester ( Tc-ECD) was used as a non-protonable standard. The capillary electrophoresis system was equipped with a radioactivity detector. Measurements were performed using a pressure-driven capillary zone electrophoresis which allowed runs even in the low pH range. For the determination of pK values, the electrophoretical a velocities of the analytes were referred to the electrophoretical velocities of tetraphenyle arsonium chloride as a positively charged marker. Calculation of pK values was accomplished by non-linear curve fitting of both structure-based equilibria a 99m equations and sigmoidal decay functions to the experimental data. Tc-MAG was shown to have a carboxyl group pK 3 a 99m value of 4.22. The value for the carboxyl groups of Tc-EC is 2.90 (determined by structure-based equil

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Author

R Jankowsky; M Friebe; B Noll; B Johannsen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

1999

Language

EN

Field

Chemistry (Physical Sciences)