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Interferon α extends the survival of human myeloma cells through an upregulation of the Mcl-1 anti-apoptotic molecule by Denis Puthier; Wilfrid Thabard; Marie-José Rapp; Marguerite Etrillard; Jean-Luc Harousseau; Régis Bataille; Martine Amiot is a Medicine article available to read on EtoBox.

What is Interferon α extends the survival of human myeloma cells through an upregulation of the Mcl-1 anti-apoptotic molecule about?

We have recently reported that Mcl‐1, an anti‐apoptotic member of the Bcl‐2 family, is upregulated by interleukin (IL)‐6 in human myeloma cells through the janus kinase/signal transducers and activators of transduction (JAK/STAT) pathway. In the current study, we have explored the effects of interferon (IFN)‐α, a cytokine which has been shown to increase myeloma cell survival. Our results demonstrate that IFN‐α potently upregulates Mcl‐1 on both myeloma cell lines and purified native myeloma cells. Of note, this upregulation is not due to an induction of an IL‐6 autocrine loop. Furthermore, we showed that IL‐6 and IFN‐α had no additive effect on Mcl‐1 upregulation, suggesting that both cytokines act through a common mechanism. Finally, the analysis of signalling transduction pathways strongly suggests that Mcl‐1 upregulation induced by IFN‐α depends on STAT3 activation. Altogether, our data show that IFN‐α has an IL‐6‐like effect on human myeloma cells and suggest that it could be deleterious in some patients.

Who reads Interferon α extends the survival of human myeloma cells through an upregulation of the Mcl-1 anti-apoptotic molecule?

Author

Denis Puthier; Wilfrid Thabard; Marie-José Rapp; Marguerite Etrillard; Jean-Luc Harousseau; Régis Bataille; Martine Amiot

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

2001

Language

EN

Field

Medicine (Health Sciences)