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Dose-Volume Determinants of Late Genitourinary Toxicity After External Beam Radiotherapy for Prostate Cancer by P. Alcantara; T.E. Schultheiss; K. Ruth; G. Shammo; S. McNeeley; E. Horwitz; A. Pollack is a Medicine article available to read on EtoBox.
What is Dose-Volume Determinants of Late Genitourinary Toxicity After External Beam Radiotherapy for Prostate Cancer about?
For the high-risk group, the corresponding 5-year control rates were: 84% (95% C.I. 57% to 94%) and 50% (95% C.I. 28% to 68%). Multivariate analysis indicates that rectal distension and high-risk disease are independent risk factors for biochemical failure, with hazard ratios of 3.89 (95% C.I. 1.58 to 9.56, pϭ0.003) and 2.45 (95% C.I. 1.18 to 5.08, pϭ0.016), respectively. The probability of residual tumor without evidence of radiation treatment (as scored by the pathologist) increased significantly with rectal distension (p ϭ 0.010, logistic analysis), and a lower incidence of grade 2 or greater late rectal bleeding within 2 years was simultaneously observed with higher CSA values (p ϭ 0.031, logistic analysis). Conclusions: We found strong evidence that rectal distension on the treatment planning CT scan decreased the probability of biochemical control, local control and rectal toxicity in patients who are treated without daily image-guided prostate localization, presumably due to geographic misses. Therefore, an empty rectum is warranted at the time simulation. These results also emphasize the need for image-guided radiotherapy to improve local control in irradiating prostate can
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- Author
- P. Alcantara; T.E. Schultheiss; K. Ruth; G. Shammo; S. McNeeley; E. Horwitz; A. Pollack
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)