Opening book details…
Can I read Inherited Coagulation Disorders in Cirrhotic Patients with Portal Vein Thrombosis on EtoBox?
Inherited Coagulation Disorders in Cirrhotic Patients with Portal Vein Thrombosis by Lucio Amitrano; Vincenzo Brancaccio; Maria Anna Guardascione; Maurizio Margaglione; Luigi Iannaccone; Giovanna D'Andrea; Riccardo Marmo; Paul R. Ames; Antonio Balzano is a Medicine article available to read on EtoBox.
What is Inherited Coagulation Disorders in Cirrhotic Patients with Portal Vein Thrombosis about?
The prevalence and pathogenesis of portal vein thrombosis (PVT) in patients with cirrhosis without hepatocellular carcinoma are not clearly defined. The role of thrombophilic genetic factors is well established in other venous thrombotic diseases, as well as in noncirrhotic portal thrombosis. Recently, new, inherited thrombophilic disorders (factor V Leiden [FVL], mutation G20210A of prothrombin [PTHR A 20210 ], and mutation TT677 of methylenetetrahydrofolate reductase [MTHFR C677=T]) have been identified and associated with increased risk of venous thrombosis. The aim of our study was to investigate the role of these thrombophilic disorders in the pathogenesis of PVT in cirrhotic patients. Twenty-three cirrhotic patients with PVT and 40 cirrhotics without PVT were included. A group of 184 patients with deep vein thrombosis (DVT) and 431 healthy persons served as controls. The FVL, PTHR A 20210 , and MTHFR C 677 =T genotypes were identified by a polymerase chain reaction and restriction analysis. The frequencies of FVL, PTHR A 20210 mutation, and homozygous MTHFR C 677 =T were 13%, 34.8%, and 43.5% in cirrhotic patients with PVT and 7.5%, 2.5%, and 5% in cirrhotic patients without
Who reads Inherited Coagulation Disorders in Cirrhotic Patients with Portal Vein Thrombosis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lucio Amitrano; Vincenzo Brancaccio; Maria Anna Guardascione; Maurizio Margaglione; Luigi Iannaccone; Giovanna D'Andrea; Riccardo Marmo; Paul R. Ames; Antonio Balzano
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)