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Baroreflex activation therapy for heart failure with reduced ejection fraction: A comprehensive systematic review and meta-analysis by Ruijie Shi; Tong Sun; Mengxi Wang; Qian Xiang; Yuhan Ding; Siyuan Yin; Yan Chen; Le Shen; Peng Yu; Xiaohu Chen is a Medicine article available to read on EtoBox.
What is Baroreflex activation therapy for heart failure with reduced ejection fraction: A comprehensive systematic review and meta-analysis about?
## Background In recent years, baroreflex activation therapy (BAT) has been utilized to treat heart failure with reduced ejection fraction (HFrEF). However, the supporting literature on its efficacy and safety is still limited. This investigation elucidates the effects of BAT in HFrEF patients to provide a reference for future clinical applications. ## Methods This investigation follows Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines. Relevant investigations on the use of BAT in HFrEF patients were searched and selected from 5 databases, including Web of Science, MEDLINE, PubMed, Embase, and Cochrane Library, from inception to December 2022. The methodological quality of eligible articles was assessed via the Cochrane risk of bias tool, and for meta-analysis, RevMan (5.3) was used. ## Results Randomized controlled trials comprising 343 participants were selected for the meta-analysis, which revealed that in HFrEF patients, BAT enhanced the levels of LVEF (MD: 2.97, 95 % CI: 0.53 to 5.41), MLHFQ (MD: −14.81, 95 % CI: −19.57 to −10.06) and 6MWT (MD: 68.18, 95 % CI: 51.62 to 84.74), whereas reduced the levels of LVEDV (MD: −15.79, 95 % CI: −
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- Author
- Ruijie Shi; Tong Sun; Mengxi Wang; Qian Xiang; Yuhan Ding; Siyuan Yin; Yan Chen; Le Shen; Peng Yu; Xiaohu Chen
- Publisher
- Elsevier
- Published
- 2024
- Language
- EN
- Field
- Medicine (Physical Sciences)