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Can I read Concordance of the Molecular Subtype Classification Between Core Needle Biopsy and Surgical Specimen in Primary Breast Cancer on EtoBox?
Concordance of the Molecular Subtype Classification Between Core Needle Biopsy and Surgical Specimen in Primary Breast Cancer by M. Pölcher; M. Braun; M. Tischitz; M. Hamann; N. Szeterlak; A. Kriegmair; C. Brambs; C. Becker; O. Stoetzer is a Medicine article available to read on EtoBox.
What is Concordance of the Molecular Subtype Classification Between Core Needle Biopsy and Surgical Specimen in Primary Breast Cancer about?
## Background: Molecular profiling of breast cancer (bc) classifies several intrinsic subtypes based on different patterns of gene expression. multigene assays estimate the risk of recurrence and help to select high-risk patients for adjuvant chemotherapy. however, these tests are associated with significant costs. immunohistochemistry (ihc) offers a surrogate classification for molecular subtypes by determining estrogen (er) and progesterone receptors (pr), human epidermal growth factor (her2neu), as well as the proliferation marker ki67. core needle biopsy (cnb) is well established in bc diagnosis and allows a pre-operative assessment of biomarkers. the aim of this study was to analyze the concordance of these markers between cnb and surgical specimens to assess whether re-testing of the surgical specimen is mandatory. ## Materials and methods: Within a 3-year period, patients with primary bc and paired samples of cnb and surgical specimens were analyzed retrospectively. concordance rates of er, pr, her2neu, ki67, and the surrogate classification for molecular subtypes were calculated using the landis and koch agreement grades. ## Results: Out of 2254 patients with primary breast
Who reads Concordance of the Molecular Subtype Classification Between Core Needle Biopsy and Surgical Specimen in Primary Breast Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- M. Pölcher; M. Braun; M. Tischitz; M. Hamann; N. Szeterlak; A. Kriegmair; C. Brambs; C. Becker; O. Stoetzer
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)