Can I read Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients on EtoBox?

Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients by Quentin Riller; Jacques Fourgeaud; Julie Bruneau; Suk See De Ravin; Grace Smith; Mathieu Fusaro; Samy Meriem; Aude Magerus; Marine Luka; Ghaith Abdessalem; Ludovic Lhermitte; Anne Jamet; Emmanuelle Six; Alessandra Magnani; Martin Castelle; Romain Lévy; Mathilde M. Lecuit; Benjamin Fournier; Sarah Winter; Michaela Semeraro; Graziella Pinto; Hanène Abid; Nizar Mahlaoui; Nathalie Cheikh; Benoit Florkin; Pierre Frange; Eric Jeziorski; Felipe Suarez; Françoise Sarrot-Reynauld; Dalila Nouar; Dominique Debray; Florence Lacaille; Capucine Picard; Philippe Pérot; Béatrice Regnault; Nicolas Da Rocha; Camille de Cevins; Laure Delage; Brieuc P. Pérot; Angélique Vinit; Francesco Carbone; Camille Brunaud; Manon Marchais; Marie-Claude Stolzenberg; Vahid Asnafi; Thierry Molina; Frédéric Rieux-Laucat; Luigi D. Notarangelo; Stefania Pittaluga; Jean Philippe Jais; Despina Moshous; Stephane Blanche; Harry Malech; Marc Eloit; Marina Cavazzana; Alain Fischer; Mickaël M. Ménager; Bénédicte Neven is a Medicine article available to read on EtoBox.

What is Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients about?

Background Allogenic hematopoietic stem cell transplantation (HSCT) and gene therapy (GT) are potentially curative treatments for severe combined immunodeficiency (SCID). Late-onset posttreatment manifestations (such as persistent hepatitis) are not uncommon. Objective We sought to characterize the prevalence and pathophysiology of persistent hepatitis in transplanted SCID patients (SCIDH+) and to evaluate risk factors and treatments. Methods We used various techniques (including pathology assessments, metagenomics, single-cell transcriptomics, and cytometry by time of flight) to perform an in-depth study of different tissues from patients in the SCIDH+ group and corresponding asymptomatic similarly transplanted SCID patients without hepatitis (SCIDH−). Results Eleven patients developed persistent hepatitis (median of 6 years after HSCT or GT). This condition was associated with the chronic detection of enteric viruses (human Aichi virus, norovirus, and sapovirus) in liver and/or stools, which were not found in stools from the SCIDH− group (n = 12). Multiomics analysis identified an expansion of effector memory CD8+ T cells with high type I and II interferon signatures. Hepatitis w

Who reads Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients?

Author

Quentin Riller; Jacques Fourgeaud; Julie Bruneau; Suk See De Ravin; Grace Smith; Mathieu Fusaro; Samy Meriem; Aude Magerus; Marine Luka; Ghaith Abdessalem; Ludovic Lhermitte; Anne Jamet; Emmanuelle Six; Alessandra Magnani; Martin Castelle; Romain Lévy; Mathilde M. Lecuit; Benjamin Fournier; Sarah Winter; Michaela Semeraro; Graziella Pinto; Hanène Abid; Nizar Mahlaoui; Nathalie Cheikh; Benoit Florkin; Pierre Frange; Eric Jeziorski; Felipe Suarez; Françoise Sarrot-Reynauld; Dalila Nouar; Dominique Debray; Florence Lacaille; Capucine Picard; Philippe Pérot; Béatrice Regnault; Nicolas Da Rocha; Camille de Cevins; Laure Delage; Brieuc P. Pérot; Angélique Vinit; Francesco Carbone; Camille Brunaud; Manon Marchais; Marie-Claude Stolzenberg; Vahid Asnafi; Thierry Molina; Frédéric Rieux-Laucat; Luigi D. Notarangelo; Stefania Pittaluga; Jean Philippe Jais; Despina Moshous; Stephane Blanche; Harry Malech; Marc Eloit; Marina Cavazzana; Alain Fischer; Mickaël M. Ménager; Bénédicte Neven

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)